A modest creature board becomes a serious combat problem with Zopandrel, Hunger Dominus. At the beginning of every combat, it doubles the power and toughness of your creatures for the turn. That includes opponents' combats, so the same effect that strengthens your attacks also creates larger blockers when the turn passes around the table.
Counter decks have a useful head start. Creatures already enlarged by Bristly Bill, Spine Sower or Branching Evolution receive a bigger temporary increase, while trample from Kodama of the West Tree helps convert the added power into damage. Extra combats can compound the growth within one turn because an earlier increase remains active when the next combat begins. The creatures do not gain counters from Zopandrel itself; this is a temporary change to their stats.
Its protection ability asks for two other creatures plus green mana or life to place an indestructible counter on it. Tokens can pay the sacrifice cost, but preserving the Dominus may mean losing attackers that would have benefited from its trigger. Decide whether protecting the multiplier is worth shrinking the army. Reach gives Zopandrel a useful defensive role even on a small board, while a wide board makes the seven-mana investment more immediately threatening. Evasion remains valuable: enormous power alone does not prevent opponents from using expendable blockers.
